SKU: 51096108975

Biotinylated MERTK/Mer Fc&Avi Tag Protein, Human

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Description

Biotinylated MERTK/Mer Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms MER, STK Kinase, Tyro12, C Eyk, C Mer, RP38 Accession Q12866 Amino Acid Sequence Ala21 Ile505, with C terminal hIgG1 Fc and Avitag Expression System HEK293 Molecular Weight 100 135kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Human
Synonyms MER, STK Kinase, Tyro12, C-Eyk, C-Mer, RP38
Accession Q12866
Amino Acid Sequence Ala21-Ile505, with C-terminal hIgG1 Fc and Avitag
Expression System HEK293
Molecular Weight 100-135kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Graham, D.K. et al. (1994) Cell Growth Differ. 5:647. 2. Graham, D.K. et al. (2006) Clin. Cancer Res. 12:2662.

Background

Tyrosine-protein Kinase Mer, also known as c-Mer and MerTK, is a member of the receptor tyrosine kinase subfamily TAM (Tyro3, Axl, and Mer). Similar to Axl and Tyro3, the extracelluar domain of Mer contains two Ig-like motifs and two fibronectin type III motifs. Mer is not expressed in normal B- and T-cells but expressed in neoplastic B- and T-cell lines . It is also show higher expression in immunosuppressive M2‑like macrophages. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.Mer is known to bind Gas6, Protein S, Tubby, Tubby-like protein 1 (Tulp1), and Galectin-3. Upon binding ligands via the Ig-like motif, Mer is dimerized to trans-autophosphorylate the kinase domain to induce downstream signaling. It has been shown that Mer signaling in macrophages induces M2 polarization, which promote tumor growth, metastasis and evasion of anti-tumor immunity in tumor microenviroment. Inhibition of Mer, especially on leukocytes and macrophages, is an effective anti-cancer therapy.

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Exchange/Return Notes
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SKU: 51096108975

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After years of fighting with cheap cables and blocks that stop working after a month, I’ve officially switched to Anker for everything. These 20W USB-C chargers work amazingly well and actually deliver the fast charging they promise for my iPhone. The build quality is on a different level compared to generic brands. They are compact, don't overheat, and the connection is rock solid every time. Save yourself the headache and just get these they are reliable, durable, and worth every penny.
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Love these. They charge iPhones very quickly as well as iPads - much better quality than other USB-C and especially better than the lightning ports. They last long and do not get hot.
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