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Description
Biotinylated EphA2 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms ECK, MPK 5, MPK5, SEK 2, SEK2, Myk2 Accession P29317 1 Amino Acid Sequence Ala24 Val537, with C terminal His and Avitag Expression System HEK293 Molecular Weight 50 55kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | ECK, MPK-5, MPK5, SEK-2, SEK2, Myk2 |
| Accession | P29317-1 |
| Amino Acid Sequence | Ala24-Val537, with C-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 50-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Ping Zhao. EphA2: A promising therapeutic target in breast cancer. J Genet Genomics. 2021 Apr 20;48(4):261-267. Epub 2021 Mar 29. |
Background
Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proliferation, survival, migration, invasion, drug resistance, metastasis, and angiogenesis. As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity, EphA2 has become a promising therapeutic target for breast cancer treatment.
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