SKU: 87703492387

Biotinylated MERTK/Mer Fc&Avi Tag Protein, Human

Sale price$250.20 Regular price$278.00
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Description

Biotinylated MERTK/Mer Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms MER, STK Kinase, Tyro12, C Eyk, C Mer, RP38 Accession Q12866 Amino Acid Sequence Ala21 Ile505, with C terminal hIgG1 Fc and Avitag Expression System HEK293 Molecular Weight 100 135kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Human
Synonyms MER, STK Kinase, Tyro12, C-Eyk, C-Mer, RP38
Accession Q12866
Amino Acid Sequence Ala21-Ile505, with C-terminal hIgG1 Fc and Avitag
Expression System HEK293
Molecular Weight 100-135kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Graham, D.K. et al. (1994) Cell Growth Differ. 5:647. 2. Graham, D.K. et al. (2006) Clin. Cancer Res. 12:2662.

Background

Tyrosine-protein Kinase Mer, also known as c-Mer and MerTK, is a member of the receptor tyrosine kinase subfamily TAM (Tyro3, Axl, and Mer). Similar to Axl and Tyro3, the extracelluar domain of Mer contains two Ig-like motifs and two fibronectin type III motifs. Mer is not expressed in normal B- and T-cells but expressed in neoplastic B- and T-cell lines . It is also show higher expression in immunosuppressive M2‑like macrophages. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.Mer is known to bind Gas6, Protein S, Tubby, Tubby-like protein 1 (Tulp1), and Galectin-3. Upon binding ligands via the Ig-like motif, Mer is dimerized to trans-autophosphorylate the kinase domain to induce downstream signaling. It has been shown that Mer signaling in macrophages induces M2 polarization, which promote tumor growth, metastasis and evasion of anti-tumor immunity in tumor microenviroment. Inhibition of Mer, especially on leukocytes and macrophages, is an effective anti-cancer therapy.

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SKU: 87703492387

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Sara Z
Waukegan, US
★★★★★ 5
Fits well and comfortable!
Size: Large, Color: Eggshell White Black Mariner Stripe, Size: Large, Color: Eggshell White Black Mariner Stripe
This shirt fits my husband very well, it is true to size. It is soft and stretchy enough to be comfortable. I bought this as part of a costume but my husband wears it around the house now because it's so comfy.
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Reviewed in the United States on December 24, 2025
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Jake Hyatt
Alexandria, US
★★★★★ 1
You get what you pay for
Size: XX-Large, Color: Eggshell White Black Mariner Stripe
Like most of the other reviews here, the shirt runs too small and too short. Material was also incredibly uncomfortable. It also wasn't the color I was hoping it would be, but that's on me for not reading the fine print (eggshell white was very much not white) If you're looking at this for a certain costume/cosplay idea, it's probably not what you're looking for.
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Reviewed in the United States on February 18, 2026
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Terrorgod
Bozeman, US
★★★★★ 5
Solid fit
Size: X-Large, Color: Eggshell White Black Mariner Stripe
Easy fit, comfortable material. Dont expect it to last forever but at the price its solid for the purpose of a halloween costume.
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Reviewed in the United States on November 1, 2025
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C.L.
New York, US
★★★★★ 3
Runs small
Size: X-Large, Color: Navy
Runs small and is short. Nice dark navy color. I ordered a size up and it is still small.
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Reviewed in the United States on February 26, 2026
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Dee
Cuba, US
★★★★★ 5
Great tee
Size: X-Large, Color: Medium Grey Heather
It’s a nice cotton material…not thin, just perfect. After washing, it also kept its shape.
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